8VWM

A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds

Summary for 8VWM

• Entry DOI: 10.2210/pdb8vwm/pdb
• Descriptor: Mitogen-activated protein kinase 14, (4P)-4-{6-[(azetidin-1-yl)methyl]-5-(2-chloro-6-fluoroanilino)-1H-indazol-1-yl}-N-methylthiophene-2-carboxamide, octyl beta-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: c-jun terminal kinase 3, jnk3, p38 alpha, kinase, selectivity, transferase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 43292.82

Authors

Park, H.,Feng, Y. (deposition date: 2024-02-01, release date: 2025-02-05)

• Primary citation: Park, H.,Feng, Y.; A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.94 Å)