8VUB

Crystal structure of wild-type HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 5e2

Summary for 8VUB

• Entry DOI: 10.2210/pdb8vub/pdb
• Related: 8VU9
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dimethoxyquinazolin-2-yl]amino}piperidin-1-yl)methyl]benzamide, ... (7 entities in total)
• Functional Keywords: non-nucleoside reverse transcriptase inhibitor, transferase, transferase-transferase inhibitor complex, viral protein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 2
• Total formula weight: 115506.40

Authors

Rumrill, S.,Ruiz, F.X.,Arnold, E. (deposition date: 2024-01-29, release date: 2025-04-30)

• Primary citation: Wang, Z.,Rumrill, S.R.,Kang, D.,Desta, S.,Feng, D.,De Clercq, E.,Pannecouque, C.,Chen, C.H.,Arnold, E.,Ruiz, F.X.,Liu, X.,Zhan, P.; Diarylpyrimidine-evolved HIV-1 non-nucleoside reverse transcriptase inhibitors show improved resistance and pharmacokinetic profiles against highly drug-resistant strains; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.18 Å)