8VU4

Structure of FabS1CE4-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor

Summary for 8VU4

Entry DOI	10.2210/pdb8vu4/pdb
Descriptor	S1CE4 VARIANT OF FAB-EPR-1 heavy chain, S1CE4 VARIANT OF FAB-EPR-1 light chain, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	proliferation, engineered antibody, high-affinity binding, enhanced crystallization, immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	95326.86
Authors	Singer, A.U.,Bruce, H.A.,Pavlenco, A.,Ploder, L.,Luu, G.,Blazer, L.,Adams, J.J.,Sidhu, S.S. (deposition date: 2024-01-28, release date: 2024-07-10)
Primary citation	Bruce, H.A.,Singer, A.U.,Blazer, L.L.,Luu, K.,Ploder, L.,Pavlenco, A.,Kurinov, I.,Adams, J.J.,Sidhu, S.S. Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33:e5081-e5081, 2024 Cited by PubMed: 38924648 DOI: 10.1002/pro.5081 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation