8VTE

Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen

Summary for 8VTE

• Entry DOI: 10.2210/pdb8vte/pdb
• Descriptor: Tiragolumab antibody light chain variable domains, Tiragolumab antibody heavy chain variable domains, T-cell immunoreceptor with Ig and ITIM domains, ... (4 entities in total)
• Functional Keywords: antibody tigit immunotherapy, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 124714.55

Authors

Fischmann, T.,Bahmanjah, S. (deposition date: 2024-01-26, release date: 2025-05-28)

• Primary citation: Fischmann, T.O.,Malashock, D.,Wang, H.,Grein, J.,Bahmanjah, S.,Ban, D.,Chien, E.,Hsieh, M.,Mayhood, T.,Yuan, J.,Beaumont, M.,Baker, J.,McCoy, M.A.,Wilson, D.,Williams, S.M.G.,Blumenschein, W.,Fayadat-Dilman, L.,Seghezzi, W.,Keenan, T.,Han, J.-H.; Pharmacological and structural characterization of vibostolimab, a novel anti-human TIGIT blocking antibody for cancer immunotherapy; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.29 Å)