8VQ3
CDK2-CyclinE1 in complex with allosteric inhibitor I-198.
This is a non-PDB format compatible entry.
Summary for 8VQ3
Entry DOI | 10.2210/pdb8vq3/pdb |
Related | 8VQ4 |
Descriptor | Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, ... (4 entities in total) |
Functional Keywords | kinase, cell cycle-transferase-inhibitor complex, cell cycle/transferase/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 67739.78 |
Authors | Hirschi, M.,Johnson, E.,Zhang, Y.,Liu, Z.,Brodsky, O.,Won, S.J.,Nagata, A.,Petroski, M.D.,Majmudar, J.D.,Niessen, S.,VanArsdale, T.,Gilbert, A.M.,Hayward, M.M.,Stewart, A.E.,Nager, A.R.,Melillo, B.,Cravatt, B. (deposition date: 2024-01-17, release date: 2024-01-31, Last modification date: 2024-02-14) |
Primary citation | Zhang, Y.,Liu, Z.,Hirschi, M.,Brodsky, O.,Johnson, E.,Won, S.J.,Nagata, A.,Petroski, M.D.,Majmudar, J.D.,Niessen, S.,VanArsdale, T.,Gilbert, A.M.,Hayward, M.M.,Stewart, A.E.,Nager, A.R.,Melillo, B.,Cravatt, B. Expanding the ligandable proteome by paralog hopping with covalent probes. Biorxiv, 2024 Cited by PubMed: 38293178DOI: 10.1101/2024.01.18.576274 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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