8VQ2
HSV1 polymerase ternary complex with dsDNA and compound 44
This is a non-PDB format compatible entry.
Summary for 8VQ2
Entry DOI | 10.2210/pdb8vq2/pdb |
Descriptor | DNA polymerase, DNA (5'-D(P*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), ... (4 entities in total) |
Functional Keywords | herpesvirus polymerase complex inhibitor, transferase |
Biological source | Human alphaherpesvirus 1 (Herpes simplex virus type 1) More |
Total number of polymer chains | 6 |
Total formula weight | 277265.65 |
Authors | |
Primary citation | Plotkin, M.A.,Labroli, M.,Schubert, J.,Shaw, A.,Schlegel, K.S.,Berger, R.,Cooke, A.J.,Hayes, R.P.,Armacost, K.A.,Kinek, K.,Krosky, P.,Burlein, C.,Meng, S.,DiNunzio, E.,Murray, E.M.,Agrawal, S.,Madeira, M.,Flattery, A.,Yao, H.,Leithead, A.,Rose 2nd, W.A.,Cox, C.,Tellers, D.M.,McKenna, P.M.,Raheem, I. Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships. Acs Med.Chem.Lett., 15:1232-1241, 2024 Cited by PubMed: 39140041DOI: 10.1021/acsmedchemlett.4c00117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.829 Å) |
Structure validation
Download full validation report