8VNX

A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds

Summary for 8VNX

Entry DOI	10.2210/pdb8vnx/pdb
Descriptor	Mitogen-activated protein kinase 10, (4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide (3 entities in total)
Functional Keywords	c-jun terminal kinase 3, jnk3, p38 alpha, kinase, selectivity, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	53094.24
Authors	Park, H.,Feng, Y. (deposition date: 2024-01-13, release date: 2025-01-15)
Primary citation	Park, H.,Feng, Y. A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds To Be Published,
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation