8VNX

A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds

Summary for 8VNX

• Entry DOI: 10.2210/pdb8vnx/pdb
• Descriptor: Mitogen-activated protein kinase 10, (4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide (3 entities in total)
• Functional Keywords: c-jun terminal kinase 3, jnk3, p38 alpha, kinase, selectivity, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 53094.24

Authors

Park, H.,Feng, Y. (deposition date: 2024-01-13, release date: 2025-01-15, Last modification date: 2026-01-28)

• Primary citation: Park, H.,Feng, Y.; Structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds; J.Mol.Struct., 1339:142179-, 2025; DOI: 10.1016/j.molstruc.2025.142179

Experimental method

X-RAY DIFFRACTION (2 Å)