8VLS

Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form)

This is a non-PDB format compatible entry.

Summary for 8VLS

• Entry DOI: 10.2210/pdb8vls/pdb
• EMDB information: 43329 43343 43392
• Descriptor: Transitional endoplasmic reticulum ATPase, (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide (2 entities in total)
• Functional Keywords: activator, complex, atpase, aaa protein, hydrolase, hydrolase-activator complex, hydrolase/activator
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 1077495.43

Authors

Jones, N.H.,Urnivicius, L.,Kapoor, T.M. (deposition date: 2024-01-12, release date: 2024-06-19)

• Primary citation: Jones, N.H.,Liu, Q.,Urnavicius, L.,Dahan, N.E.,Vostal, L.E.,Kapoor, T.M.; Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.; Proc.Natl.Acad.Sci.USA, 121:e2316892121-e2316892121, 2024; PubMed: 38833472; DOI: 10.1073/pnas.2316892121

Experimental method

ELECTRON MICROSCOPY (2.9 Å)