8VLS
Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form)
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00674 |
| Number of Residues | 19 |
| Details | AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R |
| Chain | Residue | Details |
| A | VAL341-ARG359 | |
| A | VAL617-ARG635 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20512113 |
| Chain | Residue | Details |
| A | PRO247 | |
| D | PRO247 | |
| D | ASN348 | |
| D | HIS384 | |
| E | PRO247 | |
| E | ASN348 | |
| E | HIS384 | |
| F | PRO247 | |
| F | ASN348 | |
| F | HIS384 | |
| G | PRO247 | |
| A | ASN348 | |
| G | ASN348 | |
| G | HIS384 | |
| H | PRO247 | |
| H | ASN348 | |
| H | HIS384 | |
| I | PRO247 | |
| I | ASN348 | |
| I | HIS384 | |
| J | PRO247 | |
| J | ASN348 | |
| A | HIS384 | |
| J | HIS384 | |
| K | PRO247 | |
| K | ASN348 | |
| K | HIS384 | |
| L | PRO247 | |
| L | ASN348 | |
| L | HIS384 | |
| B | PRO247 | |
| B | ASN348 | |
| B | HIS384 | |
| C | PRO247 | |
| C | ASN348 | |
| C | HIS384 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q01853 |
| Chain | Residue | Details |
| A | GLY521 | |
| J | GLY521 | |
| K | GLY521 | |
| L | GLY521 | |
| B | GLY521 | |
| C | GLY521 | |
| D | GLY521 | |
| E | GLY521 | |
| F | GLY521 | |
| G | GLY521 | |
| H | GLY521 | |
| I | GLY521 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| A | ALA2 | |
| J | ALA2 | |
| K | ALA2 | |
| L | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 | |
| E | ALA2 | |
| F | ALA2 | |
| G | ALA2 | |
| H | ALA2 | |
| I | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER3 | |
| J | SER3 | |
| K | SER3 | |
| L | SER3 | |
| B | SER3 | |
| C | SER3 | |
| D | SER3 | |
| E | SER3 | |
| F | SER3 | |
| G | SER3 | |
| H | SER3 | |
| I | SER3 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER7 | |
| C | SER13 | |
| C | SER462 | |
| C | SER702 | |
| D | SER7 | |
| D | SER13 | |
| D | SER462 | |
| D | SER702 | |
| E | SER7 | |
| E | SER13 | |
| E | SER462 | |
| A | SER13 | |
| E | SER702 | |
| F | SER7 | |
| F | SER13 | |
| F | SER462 | |
| F | SER702 | |
| G | SER7 | |
| G | SER13 | |
| G | SER462 | |
| G | SER702 | |
| H | SER7 | |
| A | SER462 | |
| H | SER13 | |
| H | SER462 | |
| H | SER702 | |
| I | SER7 | |
| I | SER13 | |
| I | SER462 | |
| I | SER702 | |
| J | SER7 | |
| J | SER13 | |
| J | SER462 | |
| A | SER702 | |
| J | SER702 | |
| K | SER7 | |
| K | SER13 | |
| K | SER462 | |
| K | SER702 | |
| L | SER7 | |
| L | SER13 | |
| L | SER462 | |
| L | SER702 | |
| B | SER7 | |
| B | SER13 | |
| B | SER462 | |
| B | SER702 | |
| C | SER7 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER37 | |
| J | SER37 | |
| K | SER37 | |
| L | SER37 | |
| B | SER37 | |
| C | SER37 | |
| D | SER37 | |
| E | SER37 | |
| F | SER37 | |
| G | SER37 | |
| H | SER37 | |
| I | SER37 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine; by VCPKMT => ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634 |
| Chain | Residue | Details |
| A | LYS315 | |
| J | LYS315 | |
| K | LYS315 | |
| L | LYS315 | |
| B | LYS315 | |
| C | LYS315 | |
| D | LYS315 | |
| E | LYS315 | |
| F | LYS315 | |
| G | LYS315 | |
| H | LYS315 | |
| I | LYS315 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | THR436 | |
| J | THR436 | |
| K | THR436 | |
| L | THR436 | |
| B | THR436 | |
| C | THR436 | |
| D | THR436 | |
| E | THR436 | |
| F | THR436 | |
| G | THR436 | |
| H | THR436 | |
| I | THR436 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 36 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q01853 |
| Chain | Residue | Details |
| A | LYS502 | |
| D | LYS502 | |
| D | LYS505 | |
| D | LYS754 | |
| E | LYS502 | |
| E | LYS505 | |
| E | LYS754 | |
| F | LYS502 | |
| F | LYS505 | |
| F | LYS754 | |
| G | LYS502 | |
| A | LYS505 | |
| G | LYS505 | |
| G | LYS754 | |
| H | LYS502 | |
| H | LYS505 | |
| H | LYS754 | |
| I | LYS502 | |
| I | LYS505 | |
| I | LYS754 | |
| J | LYS502 | |
| J | LYS505 | |
| A | LYS754 | |
| J | LYS754 | |
| K | LYS502 | |
| K | LYS505 | |
| K | LYS754 | |
| L | LYS502 | |
| L | LYS505 | |
| L | LYS754 | |
| B | LYS502 | |
| B | LYS505 | |
| B | LYS754 | |
| C | LYS502 | |
| C | LYS505 | |
| C | LYS754 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q01853 |
| Chain | Residue | Details |
| A | LYS668 | |
| J | LYS668 | |
| K | LYS668 | |
| L | LYS668 | |
| B | LYS668 | |
| C | LYS668 | |
| D | LYS668 | |
| E | LYS668 | |
| F | LYS668 | |
| G | LYS668 | |
| H | LYS668 | |
| I | LYS668 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 24 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | SER770 | |
| E | SER775 | |
| F | SER770 | |
| F | SER775 | |
| G | SER770 | |
| G | SER775 | |
| H | SER770 | |
| H | SER775 | |
| I | SER770 | |
| I | SER775 | |
| J | SER770 | |
| A | SER775 | |
| J | SER775 | |
| K | SER770 | |
| K | SER775 | |
| L | SER770 | |
| L | SER775 | |
| B | SER770 | |
| B | SER775 | |
| C | SER770 | |
| C | SER775 | |
| D | SER770 | |
| D | SER775 | |
| E | SER770 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | SER787 | |
| J | SER787 | |
| K | SER787 | |
| L | SER787 | |
| B | SER787 | |
| C | SER787 | |
| D | SER787 | |
| E | SER787 | |
| F | SER787 | |
| G | SER787 | |
| H | SER787 | |
| I | SER787 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q01853 |
| Chain | Residue | Details |
| A | TYR805 | |
| J | TYR805 | |
| K | TYR805 | |
| L | TYR805 | |
| B | TYR805 | |
| C | TYR805 | |
| D | TYR805 | |
| E | TYR805 | |
| F | TYR805 | |
| G | TYR805 | |
| H | TYR805 | |
| I | TYR805 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 36 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS8 | |
| D | LYS8 | |
| D | LYS18 | |
| E | LYS8 | |
| E | LYS18 | |
| F | LYS8 | |
| F | LYS18 | |
| G | LYS8 | |
| G | LYS18 | |
| H | LYS8 | |
| H | LYS18 | |
| I | LYS8 | |
| I | LYS18 | |
| J | LYS8 | |
| A | LYS18 | |
| J | LYS18 | |
| K | LYS8 | |
| K | LYS18 | |
| L | LYS8 | |
| L | LYS18 | |
| B | LYS8 | |
| B | LYS18 | |
| C | LYS8 | |
| C | LYS18 |
