8VKZ

Crystal structure of Glucocorticoid Receptor in complex with an inhibitor

これはPDB形式変換不可エントリーです。

8VKZ の概要

• エントリーDOI: 10.2210/pdb8vkz/pdb
• 分子名称: Glucocorticoid receptor, Nuclear receptor coactivator 2, (4aR,4bS,5R,6aS,6bS,8R,9aR,10aR,10bR)-8-{4-[(3-aminophenyl)methyl]phenyl}-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, ... (4 entities in total)
• 機能のキーワード: glucocorticord receptor, modulator, transcription, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63143.28

構造登録者

Judge, R.A.,Hobson, A.D. (登録日: 2024-01-10, 公開日: 2024-01-24, 最終更新日: 2024-05-08)

• 主引用文献: Hobson, A.D.,Zhu, H.,Qiu, W.,Judge, R.A.,Longenecker, K.; Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties.; Rsc Med Chem, 15:832-838, 2024; PubMed: 38516584; DOI: 10.1039/d3md00540b

実験手法

X-RAY DIFFRACTION (2.133 Å)