8VKA
Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 9c
This is a non-PDB format compatible entry.
Summary for 8VKA
Entry DOI | 10.2210/pdb8vka/pdb |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, N-[1,5-dimethyl-4-(2-{[(2M)-2'-(piperazin-1-yl)[2,4'-bipyridin]-3-yl]oxy}ethyl)-1H-pyrazole-3-carbonyl]glycine, ... (9 entities in total) |
Functional Keywords | enzyme, inhibitor, complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase |
Biological source | Plasmodium vivax Sal-1 |
Total number of polymer chains | 3 |
Total formula weight | 141628.36 |
Authors | Fenwick, M.K.,Staker, B.L.,Phan, I.Q.,Early, J.,Myler, P.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2024-01-08, release date: 2024-07-17) |
Primary citation | Rodriguez-Hernandez, D.,Fenwick, M.K.,Zigweid, R.,Sankaran, B.,Myler, P.J.,Sunnerhagen, P.,Kaushansky, A.,Staker, B.L.,Grotli, M. Exploring Subsite Selectivity within Plasmodium vivax N -Myristoyltransferase Using Pyrazole-Derived Inhibitors. J.Med.Chem., 67:7312-7329, 2024 Cited by PubMed: 38680035DOI: 10.1021/acs.jmedchem.4c00168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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