8VKA

Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 9c

これはPDB形式変換不可エントリーです。

8VKA の概要

• エントリーDOI: 10.2210/pdb8vka/pdb
• 分子名称: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, N-[1,5-dimethyl-4-(2-{[(2M)-2'-(piperazin-1-yl)[2,4'-bipyridin]-3-yl]oxy}ethyl)-1H-pyrazole-3-carbonyl]glycine, ... (9 entities in total)
• 機能のキーワード: enzyme, inhibitor, complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase
• 由来する生物種: Plasmodium vivax Sal-1
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 141628.36

構造登録者

Fenwick, M.K.,Staker, B.L.,Phan, I.Q.,Early, J.,Myler, P.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2024-01-08, 公開日: 2024-07-17)

• 主引用文献: Rodriguez-Hernandez, D.,Fenwick, M.K.,Zigweid, R.,Sankaran, B.,Myler, P.J.,Sunnerhagen, P.,Kaushansky, A.,Staker, B.L.,Grotli, M.; Exploring Subsite Selectivity within Plasmodium vivax N -Myristoyltransferase Using Pyrazole-Derived Inhibitors.; J.Med.Chem., 67:7312-7329, 2024; PubMed: 38680035; DOI: 10.1021/acs.jmedchem.4c00168

実験手法

X-RAY DIFFRACTION (1.97 Å)