8VHV

Transmembrane AMPA Receptor Regulatory Protein Subunit Gamma 2

Summary for 8VHV

• Entry DOI: 10.2210/pdb8vhv/pdb
• EMDB information: 43242
• Descriptor: Voltage-dependent calcium channel gamma-2 subunit (1 entity in total)
• Functional Keywords: tetraspanin, glutamate receptor regulator protein, claudin-like, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 23196.71

Authors

Hale, W.D.,Montano Romero, A.,Huganir, R.L.,Twomey, E.C. (deposition date: 2024-01-02, release date: 2025-01-22, Last modification date: 2025-01-29)

Primary citation

Hale, W.D.,Romero, A.M.,Koylass, N.,Warrick, C.R.,Qiu, Z.,Huganir, R.L.,Twomey, E.C.
Structure of transmembrane AMPA receptor regulatory protein subunit gamma 2.
Nat Commun, 16:671-671, 2025

PubMed Abstract: Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. With cryo-electron microscopy (cryo-EM) we reconstruct the 36 kDa TARP subunit γ2 to 2.3 Å, which points to structural diversity among TARPs. Our data reveals critical motifs that distinguish TARPs from claudins and define how sequence variations within TARPs differentiate subfamilies and their regulation of AMPARs.

PubMed: 39809794
DOI: 10.1038/s41467-025-56027-1

Experimental method

ELECTRON MICROSCOPY (2.3 Å)