8VHV

Transmembrane AMPA Receptor Regulatory Protein Subunit Gamma 2

Summary for 8VHV

Entry DOI	10.2210/pdb8vhv/pdb
EMDB information	43242
Descriptor	Voltage-dependent calcium channel gamma-2 subunit (1 entity in total)
Functional Keywords	tetraspanin, glutamate receptor regulator protein, claudin-like, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	23196.71
Authors	Hale, W.D.,Montano Romero, A.,Huganir, R.L.,Twomey, E.C. (deposition date: 2024-01-02, release date: 2025-01-22)
Primary citation	Hale, W.D.,Romero, A.M.,Huganir, R.L.,Twomey, E.C. Structure of Transmembrane AMPA Receptor Regulatory Protein Subunit gamma 2 bioRxiv, 2023 Cited by PubMed Abstract: Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. We used cryo-electron microscopy (cryo-EM) to reconstruct the 36 kDa TARP subunit γ2 to 2.3 Å and reveal the structural diversity of TARPs. Our data reveals critical motifs that distinguish TARPs from claudins and define how sequence variations within TARPs differentiate subfamilies and their regulation of AMPARs. PubMed: 38076787 DOI: 10.1038/s41586-023-06528-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.3 Å)

Structure validation