8VHR

Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and GTP

8VHR の概要

• エントリーDOI: 10.2210/pdb8vhr/pdb
• 関連するPDBエントリー: 8VHN 8VHO 8VHP 8VHQ 8VHU
• 分子名称: Ribonucleoside-diphosphate reductase 1 subunit alpha, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: ribonucleotide reductase, allosteric regulation, nucleotide binding, subunit interaction, oxidoreductase
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 356944.65

構造登録者

Funk, M.A.,Zimanyi, C.M.,Drennan, C.L. (登録日: 2024-01-02, 公開日: 2024-09-04, 最終更新日: 2024-10-09)

• 主引用文献: Funk, M.A.,Zimanyi, C.M.,Andree, G.A.,Hamilos, A.E.,Drennan, C.L.; How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.; Biochemistry, 63:2517-2531, 2024; PubMed: 39164005; DOI: 10.1021/acs.biochem.4c00329

実験手法

X-RAY DIFFRACTION (3.55 Å)