8VHO

Crystal Structure of E. coli class Ia ribonucleotide reductase alpha subunit bound to dATP

Summary for 8VHO

• Entry DOI: 10.2210/pdb8vho/pdb
• Related: 8VHN 8VHP 8VHQ 8VHR 8VHU
• Descriptor: Ribonucleoside-diphosphate reductase 1 subunit alpha, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: ribonucleotide reductase, allosteric regulation, nucleotide binding, subunit interaction, oxidoreductase
• Biological source: Escherichia coli K-12
• Total number of polymer chains: 2
• Total formula weight: 174390.78

Authors

Funk, M.A.,Zimanyi, C.M.,Drennan, C.L. (deposition date: 2024-01-02, release date: 2024-09-04)

• Primary citation: Funk, M.A.,Zimanyi, C.M.,Andree, G.A.,Hamilos, A.E.,Drennan, C.L.; How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase.; Biochemistry, 2024; PubMed: 39164005; DOI: 10.1021/acs.biochem.4c00329

Experimental method

X-RAY DIFFRACTION (2.548 Å)