8VCY

Human TCR A2.13 in complex with DQ8-InsC8-15NPY

Summary for 8VCY

• Entry DOI: 10.2210/pdb8vcy/pdb
• Related: 8VCX
• Descriptor: MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, Hybrid insulin peptide (HIP; InsC8-15-NPY68-74), ... (9 entities in total)
• Functional Keywords: immune receptor complex, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 96155.52

Authors

Tran, T.M.,Lim, J.J.,Loh, T.Y.,Mannering, I.S.,Rossjohn, J.,Reid, H.H. (deposition date: 2023-12-14, release date: 2024-08-07, Last modification date: 2024-09-04)

• Primary citation: Tran, M.T.,Lim, J.J.,Loh, T.J.,Mannering, S.I.,Rossjohn, J.,Reid, H.H.; A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8.; J.Biol.Chem., 300:107612-107612, 2024; PubMed: 39074636; DOI: 10.1016/j.jbc.2024.107612

Experimental method

X-RAY DIFFRACTION (2.6 Å)