8VCY
Human TCR A2.13 in complex with DQ8-InsC8-15NPY
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MHC class II HLA-DQ-alpha chain | polymer | 185 | 21124.5 | 1 | UniProt (Q30069) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | DQA1*03:01 (DQ8-alpha chain) |
| 2 | B (B) | MHC class II HLA-DQ-beta-1 | polymer | 192 | 22605.4 | 1 | UniProt (O19707) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | DQB1*03:02 (DQ8-beta chain) |
| 3 | C (C) | Hybrid insulin peptide (HIP; InsC8-15-NPY68-74) | polymer | 15 | 1433.5 | 1 | Homo sapiens (human) | ||
| 4 | D (D) | T-CELL-RECEPTOR, TCR A2.13 alpha | polymer | 203 | 22633.2 | 1 | Homo sapiens (human) | ||
| 5 | E (E) | T-CELL-RECEPTOR, TCR A2.13 beta | polymer | 239 | 27076.1 | 1 | Homo sapiens (human) | ||
| 6 | F, H (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 7 | G, I, J, N, O (A, B, D, E) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 8 | K, L, M, P (D, E) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 9 | Q, R, S, T, U (A, B, C, D, E) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A: -1 - 181 (UniProt: Q30069)
| PDB | External Database | Details |
|---|---|---|
| Cys 72 | Ile 75 | engineered mutation |
| Ser 182 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94872.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1282.8 | |
| All* | Total formula weight | 96155.5 |
