8V91

Structure of human AQP4 with a pathogenic autoantibody- rAB 58

Summary for 8V91

• Entry DOI: 10.2210/pdb8v91/pdb
• EMDB information: 43047
• Descriptor: Aquaporin-4, rAB 58 Light Chain, rAB 58 Heavy Chain, ... (4 entities in total)
• Functional Keywords: aquaporin, water-channel, transport protein-immune system complex, neuromyelitis optica (nmo), autoimmune disease, transport protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 186370.55

Authors

Gupta, M.,Khandelwal, N.K.,Stroud, R.M. (deposition date: 2023-12-07, release date: 2024-12-11, Last modification date: 2025-05-14)

• Primary citation: Gupta, M.,Khandelwal, N.K.,Stroud, R.M.; Human AQP4 structure in lipid nanodisc using cryo-EM; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)