8V6U
5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking
Summary for 8V6U
Entry DOI | 10.2210/pdb8v6u/pdb |
EMDB information | 42999 |
Descriptor | 5-hydroxytryptamine receptor 2A, G protein alpha-subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total) |
Functional Keywords | active state gpcr, heterotrimer, complex, serotonin, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 142472.79 |
Authors | Gumpper, R.H.,Wang, L.,Kapolka, N.,Skiniotis, G.,Roth, B.L. (deposition date: 2023-12-03, release date: 2024-05-29, Last modification date: 2024-07-03) |
Primary citation | Lyu, J.,Kapolka, N.,Gumpper, R.,Alon, A.,Wang, L.,Jain, M.K.,Barros-Alvarez, X.,Sakamoto, K.,Kim, Y.,DiBerto, J.,Kim, K.,Glenn, I.S.,Tummino, T.A.,Huang, S.,Irwin, J.J.,Tarkhanova, O.O.,Moroz, Y.,Skiniotis, G.,Kruse, A.C.,Shoichet, B.K.,Roth, B.L. AlphaFold2 structures guide prospective ligand discovery. Science, 384:eadn6354-eadn6354, 2024 Cited by PubMed: 38753765DOI: 10.1126/science.adn6354 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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