8V6R

Crystal structure of EcThsA in complex with ADPR

Summary for 8V6R

• Entry DOI: 10.2210/pdb8v6r/pdb
• Descriptor: Thoeris protein ThsA Macro domain-containing protein, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE (3 entities in total)
• Functional Keywords: antiphage immunity, nucleotide signalling, immune system
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 56733.63

Authors

Shi, Y.,Masic, V.,Mosaiab, T.,Goulart, C.C.,Hartley-Tassell, L.,Sorbello, M.,Vasquez, E.,Mishra, B.P.,Holt, S.,Gu, W.,Kobe, B.,Ve, T. (deposition date: 2023-12-02, release date: 2024-06-12, Last modification date: 2024-07-10)

• Primary citation: Shi, Y.,Masic, V.,Mosaiab, T.,Rajaratman, P.,Hartley-Tassell, L.,Sorbello, M.,Goulart, C.C.,Vasquez, E.,Mishra, B.P.,Holt, S.,Gu, W.,Kobe, B.,Ve, T.; Structural characterization of macro domain-containing Thoeris antiphage defense systems.; Sci Adv, 10:eadn3310-eadn3310, 2024; PubMed: 38924412; DOI: 10.1126/sciadv.adn3310

Experimental method

X-RAY DIFFRACTION (2.14 Å)