8V58
Complex of murine cathepsin K with bound heparan sulfate 12mer
Summary for 8V58
Entry DOI | 10.2210/pdb8v58/pdb |
Descriptor | Cathepsin K, beta-D-galactopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... (6 entities in total) |
Functional Keywords | complex, heparan sulfate, protease, collagenase, hydrolase |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 2 |
Total formula weight | 51638.97 |
Authors | |
Primary citation | Zhang, X.,Luo, Y.,Hao, H.,Krahn, J.M.,Su, G.,Dutcher, R.,Xu, Y.,Liu, J.,Pedersen, L.C.,Xu, D. Heparan sulfate selectively inhibits the collagenase activity of cathepsin K. Matrix Biol., 129:15-28, 2024 Cited by PubMed: 38548090DOI: 10.1016/j.matbio.2024.03.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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