8V4X

Structure of MALT1 in complex with an allosteric inhibitor

これはPDB形式変換不可エントリーです。

8V4X の概要

• エントリーDOI: 10.2210/pdb8v4x/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001076
• 分子名称: Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Inhibitor peptide, N-{7-[(1S)-1-methoxyethyl]-2-methyl[1,3]thiazolo[5,4-b]pyridin-6-yl}-N'-[6-(2H-1,2,3-triazol-2-yl)-5-(trifluoromethyl)pyridin-3-yl]urea, ... (4 entities in total)
• 機能のキーワード: hydrolase, allosteric inhibitor., hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 269253.47

構造登録者

Judge, R.A.,Pappano, W.N. (登録日: 2023-11-29, 公開日: 2024-05-01, 最終更新日: 2024-07-10)

• 主引用文献: Plotnik, J.P.,Richardson, A.E.,Yang, H.,Rojas, E.,Bontcheva, V.,Dowell, C.,Parsons, S.,Wilson, A.,Ravanmehr, V.,Will, C.,Jung, P.,Zhu, H.,Partha, S.K.,Panchal, S.C.,Mali, R.S.,Kohlhapp, F.J.,McClure, R.A.,Ramathal, C.Y.,George, M.D.,Jhala, M.,Elsen, N.L.,Qiu, W.,Judge, R.A.,Pan, C.,Mastracchio, A.,Henderson, J.,Meulbroek, J.A.,Green, M.R.,Pappano, W.N.; Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma.; Mol.Cancer Ther., 23:949-960, 2024; PubMed: 38507740; DOI: 10.1158/1535-7163.MCT-23-0518

実験手法

X-RAY DIFFRACTION (2.486 Å)