8V0C

Structure of TDP1 catalytic domain complexed with compound IB06

8V0C の概要

• エントリーDOI: 10.2210/pdb8v0c/pdb
• 分子名称: Tyrosyl-DNA phosphodiesterase 1, 1,2-ETHANEDIOL, (8M)-8-(2-{[2-(fluorosulfonyl)ethyl]amino}phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: phosphodiesterase, drug target, cancer, dna binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105820.36

構造登録者

Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke Jr., T.R. (登録日: 2023-11-17, 公開日: 2024-09-25, 最終更新日: 2024-10-23)

• 主引用文献: Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke Jr., T.R.; Structures of TDP1 complexed with inhibitors; To Be Published,

実験手法

X-RAY DIFFRACTION (1.62 Å)