8UXM

Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin

This is a non-PDB format compatible entry.

Summary for 8UXM

• Entry DOI: 10.2210/pdb8uxm/pdb
• EMDB information: 42769
• Descriptor: Calmodulin-1, Ryanodine receptor 2, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... (6 entities in total)
• Functional Keywords: calcium channel, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 2380985.33

Authors

Miotto, M.C.,Marks, A.R. (deposition date: 2023-11-09, release date: 2023-11-22, Last modification date: 2024-10-02)

• Primary citation: Miotto, M.C.,Reiken, S.,Wronska, A.,Yuan, Q.,Dridi, H.,Liu, Y.,Weninger, G.,Tchagou, C.,Marks, A.R.; Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.; Nat Commun, 15:8080-8080, 2024; PubMed: 39278969; DOI: 10.1038/s41467-024-51791-y

Experimental method

ELECTRON MICROSCOPY (3.56 Å)