8UWZ

The structure of Raamsizumab in complex with VEGF121

Summary for 8UWZ

• Entry DOI: 10.2210/pdb8uwz/pdb
• Descriptor: Raamsizumab heavy chain, Raamsizumab light chain S1C variant, Isoform VEGF121 of Vascular endothelial growth factor A, long form, ... (5 entities in total)
• Functional Keywords: signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 125130.04

Authors

Singer, A.U.,Bruce, H.,Blazer, L.,Sicheri, F.,Adams, J.J.,Sidhu, S.S. (deposition date: 2023-11-08, release date: 2024-11-13)

• Primary citation: Fellouse, F.A.,Harit, R.K.,Arun, S.,Arora, R.,Wagner, N.,Antony, A.,Wong, S.,Yang, N.,Rajakrishnan, S.,Anthony, M.,Gokul, S.,Vinodh, S.,Bhunia, S.,Vinothini, T.M.,Choubey, S.,Rajendran, A.,Srivastava, A.,Seshagiri, S.,Gross, M.L.,Leung, D.W.,Amarasinghe, G.K.,Chaudhuri, A.,Sidhu, S.S.,Ramchand, C.N.; Raamsizumab: A Potent Synthetic Human Anti-VEGF Neutralizing Fab for Treatment of Ocular Neovascularization Diseases; to be published,

Experimental method

X-RAY DIFFRACTION (3.5 Å)