8UW2

Structure of AKT1(E17K) with compound 3 (zinc-free)

Summary for 8UW2

• Entry DOI: 10.2210/pdb8uw2/pdb
• Related: 8UVY
• Descriptor: RAC-alpha serine/threonine-protein kinase, NB41, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: inhibitor, kinase, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 66307.19

Authors

Craven, G.B.,Taunton, J. (deposition date: 2023-11-05, release date: 2024-09-04)

• Primary citation: Craven, G.B.,Taunton, J.; Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)