8UW1

Cryo-EM structure of DNMT3A1 UDR in complex with H2AK119Ub-nucleosome

Summary for 8UW1

• Entry DOI: 10.2210/pdb8uw1/pdb
• EMDB information: 42636
• Descriptor: Histone H3.2, Histone H4, Histone H2A, ... (7 entities in total)
• Functional Keywords: dnmt3a1, chromatin, h2a lysine 119 monoubiquitination, dna methyltransferase, gene regulation
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 11
• Total formula weight: 208966.33

Authors

Gretarsson, K.,Abini-Agbomson, S.,Armache, K.-J.,Lu, C. (deposition date: 2023-11-05, release date: 2024-09-11)

• Primary citation: Gretarsson, K.H.,Abini-Agbomson, S.,Gloor, S.L.,Weinberg, D.N.,McCuiston, J.L.,Kumary, V.U.S.,Hickman, A.R.,Sahu, V.,Lee, R.,Xu, X.,Lipieta, N.,Flashner, S.,Adeleke, O.A.,Popova, I.K.,Taylor, H.F.,Noll, K.,Windham, C.L.,Maryanski, D.N.,Venters, B.J.,Nakagawa, H.,Keogh, M.C.,Armache, K.J.,Lu, C.; Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.; Sci Adv, 10:eadp0975-eadp0975, 2024; PubMed: 39196936; DOI: 10.1126/sciadv.adp0975

Experimental method

ELECTRON MICROSCOPY (2.88 Å)