8UV0
Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
Summary for 8UV0
Entry DOI | 10.2210/pdb8uv0/pdb |
Descriptor | Cyclin-dependent kinase 2, 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol (3 entities in total) |
Functional Keywords | cdk2, serine/threonine kinase, cell cycle regulation, aminopyrimidine, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34333.82 |
Authors | Deller, M.C.,Epling, L.B. (deposition date: 2023-11-02, release date: 2024-02-14, Last modification date: 2024-03-06) |
Primary citation | Hummel, J.R.,Xiao, K.J.,Yang, J.C.,Epling, L.B.,Mukai, K.,Ye, Q.,Xu, M.,Qian, D.,Huo, L.,Weber, M.,Roman, V.,Lo, Y.,Drake, K.,Stump, K.,Covington, M.,Kapilashrami, K.,Zhang, G.,Ye, M.,Diamond, S.,Yeleswaram, S.,Macarron, R.,Deller, M.C.,Wee, S.,Kim, S.,Wang, X.,Wu, L.,Yao, W. Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2. J.Med.Chem., 67:3112-3126, 2024 Cited by PubMed: 38325398DOI: 10.1021/acs.jmedchem.3c02287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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