8UV0

Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 2	polymer	297	33845.3	1	UniProt (P24941) Pfam (PF00069) In PDB	Homo sapiens (human)	Cell division protein kinase 2,p33 protein kinase
2	A	1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol	non-polymer		488.5	1	Chemie (XKU)
3		water	water		18.0	122	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33845.3
Non-Polymers*	Number of molecules	1
	Total formula weight	488.5
All*	Total formula weight	34333.8

*Water molecules are not included.