8UPA
Structure of gp130 in complex with a de novo designed IL-6 mimetic
Summary for 8UPA
Entry DOI | 10.2210/pdb8upa/pdb |
Descriptor | De novo designed IL-6 mimetic, Interleukin-6 receptor subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | cytokine receptor, de novo design, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 60536.92 |
Authors | |
Primary citation | Huang, B.,Coventry, B.,Borowska, M.T.,Arhontoulis, D.C.,Exposit, M.,Abedi, M.,Jude, K.M.,Halabiya, S.F.,Allen, A.,Cordray, C.,Goreshnik, I.,Ahlrichs, M.,Chan, S.,Tunggal, H.,DeWitt, M.,Hyams, N.,Carter, L.,Stewart, L.,Fuller, D.H.,Mei, Y.,Garcia, K.C.,Baker, D. De novo design of miniprotein antagonists of cytokine storm inducers. Nat Commun, 15:7064-7064, 2024 Cited by PubMed: 39152100DOI: 10.1038/s41467-024-50919-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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