8UPA

Structure of gp130 in complex with a de novo designed IL-6 mimetic

Summary for 8UPA

Entry DOI	10.2210/pdb8upa/pdb
Descriptor	De novo designed IL-6 mimetic, Interleukin-6 receptor subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	cytokine receptor, de novo design, cytokine
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	60536.92
Authors	Borowska, M.T.,Jude, K.M.,Garcia, K.C. (deposition date: 2023-10-22, release date: 2024-08-28)
Primary citation	Huang, B.,Coventry, B.,Borowska, M.T.,Arhontoulis, D.C.,Exposit, M.,Abedi, M.,Jude, K.M.,Halabiya, S.F.,Allen, A.,Cordray, C.,Goreshnik, I.,Ahlrichs, M.,Chan, S.,Tunggal, H.,DeWitt, M.,Hyams, N.,Carter, L.,Stewart, L.,Fuller, D.H.,Mei, Y.,Garcia, K.C.,Baker, D. De novo design of miniprotein antagonists of cytokine storm inducers. Nat Commun, 15:7064-7064, 2024 Cited by PubMed: 39152100 DOI: 10.1038/s41467-024-50919-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation