8UPA

Structure of gp130 in complex with a de novo designed IL-6 mimetic

8UPA の概要

• エントリーDOI: 10.2210/pdb8upa/pdb
• 分子名称: De novo designed IL-6 mimetic, Interleukin-6 receptor subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: cytokine receptor, de novo design, cytokine
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 60536.92

構造登録者

Borowska, M.T.,Jude, K.M.,Garcia, K.C. (登録日: 2023-10-22, 公開日: 2024-08-28)

• 主引用文献: Huang, B.,Coventry, B.,Borowska, M.T.,Arhontoulis, D.C.,Exposit, M.,Abedi, M.,Jude, K.M.,Halabiya, S.F.,Allen, A.,Cordray, C.,Goreshnik, I.,Ahlrichs, M.,Chan, S.,Tunggal, H.,DeWitt, M.,Hyams, N.,Carter, L.,Stewart, L.,Fuller, D.H.,Mei, Y.,Garcia, K.C.,Baker, D.; De novo design of miniprotein antagonists of cytokine storm inducers.; Nat Commun, 15:7064-7064, 2024; PubMed: 39152100; DOI: 10.1038/s41467-024-50919-4

実験手法

X-RAY DIFFRACTION (3.3 Å)