8UNW
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class L)
Summary for 8UNW
Entry DOI | 10.2210/pdb8unw/pdb |
EMDB information | 42419 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | gpcr, adrenergic, receptor, g protein, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 142260.95 |
Authors | Papasergi-Scott, M.M.,Skiniotis, G. (deposition date: 2023-10-19, release date: 2024-03-06, Last modification date: 2024-06-05) |
Primary citation | Papasergi-Scott, M.M.,Perez-Hernandez, G.,Batebi, H.,Gao, Y.,Eskici, G.,Seven, A.B.,Panova, O.,Hilger, D.,Casiraghi, M.,He, F.,Maul, L.,Gmeiner, P.,Kobilka, B.K.,Hildebrand, P.W.,Skiniotis, G. Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629:1182-1191, 2024 Cited by PubMed: 38480881DOI: 10.1038/s41586-024-07153-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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