8UND

X-ray Structure of SARS-CoV-2 main protease covalently bound to inhibitor GRL-190-21 at 1.90 A.

Summary for 8UND

• Entry DOI: 10.2210/pdb8und/pdb
• Descriptor: ORF1a polyprotein, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopiperidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
• Functional Keywords: main protease, 3c like protease, 3clpro, mpro, nirmatrelvir, inhibitor, covid-19, sars-cov-2, structural genomics, center for structural biology of infectious diseases, csbid, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus
• Total number of polymer chains: 1
• Total formula weight: 34341.12

Authors

Mesecar, A.D.,Lendy, E.K.,Ghosh, A.K.,Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2023-10-18, release date: 2024-10-23)

• Primary citation: Mesecar, A.D.,Lendy, E.K.,Ghosh, A.K.; X-ray Structure of SARS-CoV-2 main protease covalently bound to inhibitor GRL-190-21 at 1.90 A.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)