8UKX

Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 7.0

Summary for 8UKX

• Entry DOI: 10.2210/pdb8ukx/pdb
• Related: 8UKV 8UKW
• Descriptor: Epidermal growth factor receptor, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: cell surface receptor, glycoprotein, extracellular, glioblastoma, oncogenic variant, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 40020.23

Authors

Stayrook, S.E.,Ferguson, K.M. (deposition date: 2023-10-15, release date: 2024-06-12, Last modification date: 2024-07-03)

• Primary citation: Bagchi, A.,Stayrook, S.E.,Xenaki, K.T.,Starbird, C.A.,Doulkeridou, S.,El Khoulati, R.,Roovers, R.C.,Schmitz, K.R.,van Bergen En Henegouwen, P.M.P.,Ferguson, K.M.; Structural insights into the role and targeting of EGFRvIII.; Structure, 2024; PubMed: 38908376; DOI: 10.1016/j.str.2024.05.018

Experimental method

X-RAY DIFFRACTION (3.301 Å)