8UKV

Crystal structure of nanobody/VHH domain of 34E5 in complex with the extracellular region of the epidermal growth factor variant III (EGFRvIII)

Summary for 8UKV

• Entry DOI: 10.2210/pdb8ukv/pdb
• Related: 8UKW 8UKX
• Descriptor: Epidermal growth factor receptor, Nanobody/VHH domain 34E5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: cell surface receptor, glycoprotein, extracellular, glioblastoma, oncogenic variant, nanobody, vhh domain, camelid vh domain, antibody, antigen, antibody complex, transferase-immune system complex, transferase, transferase/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 111436.20

Authors

Stayrook, S.E.,Ferguson, K.M.,Bagchi, A. (deposition date: 2023-10-15, release date: 2024-06-19, Last modification date: 2024-07-03)

• Primary citation: Bagchi, A.,Stayrook, S.E.,Xenaki, K.T.,Starbird, C.A.,Doulkeridou, S.,El Khoulati, R.,Roovers, R.C.,Schmitz, K.R.,van Bergen En Henegouwen, P.M.P.,Ferguson, K.M.; Structural insights into the role and targeting of EGFRvIII.; Structure, 2024; PubMed: 38908376; DOI: 10.1016/j.str.2024.05.018

Experimental method

X-RAY DIFFRACTION (2.94 Å)