8UK5

Crystal structure of the bromodomain of human ATAD2B in complex with histone H4S1(ph)K5ac

8UK5 の概要

• エントリーDOI: 10.2210/pdb8uk5/pdb
• 分子名称: ATPase family AAA domain-containing protein 2B, Histone H4S1(ph)K5ac (3 entities in total)
• 機能のキーワード: bromodomain, epigenetics, chromatin reader domain, protein binding, histone acetylation, peptide binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 17166.50

構造登録者

Montgomery, C.,Phillips, M.,Nix, J.C.,Glass, K.C. (登録日: 2023-10-12, 公開日: 2024-06-05)

• 主引用文献: Phillips, M.,Malone, K.L.,Boyle, B.W.,Montgomery, C.,Kressy, I.A.,Joseph, F.M.,Bright, K.M.,Boyson, S.P.,Chang, S.,Nix, J.C.,Young, N.L.,Jeffers, V.,Frietze, S.,Glass, K.C.; Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains.; J.Med.Chem., 67:8186-8200, 2024; PubMed: 38733345; DOI: 10.1021/acs.jmedchem.4c00210

実験手法

X-RAY DIFFRACTION (1.4 Å)