8UJV
Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide opposite urea lesion
Summary for 8UJV
Entry DOI | 10.2210/pdb8ujv/pdb |
Descriptor | DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(UD8)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total) |
Functional Keywords | translation synthesis dna polymerase, urea-containing dna, non-hydrolysable nucleotide, dna binding protein, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 55222.53 |
Authors | Tomar, R.,Egli, M.,Stone, M.P. (deposition date: 2023-10-11, release date: 2024-03-20, Last modification date: 2024-05-01) |
Primary citation | Tomar, R.,Li, S.,Egli, M.,Stone, M.P. Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta. Biochemistry, 63:754-766, 2024 Cited by PubMed: 38413007DOI: 10.1021/acs.biochem.3c00569 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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