8UHB

Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex

Summary for 8UHB

Entry DOI	10.2210/pdb8uhb/pdb
EMDB information	42268
Descriptor	Soluble cytochrome b562,Beta-2 adrenergic receptor,Trace amine-associated receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
Functional Keywords	gpcr, signaling complex, trace amine-associated receptor, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	168035.26
Authors	Zilberg, G.,Warren, A.L.,Parpounas, A.K.,Wacker, D. (deposition date: 2023-10-08, release date: 2024-01-10, Last modification date: 2024-05-01)
Primary citation	Zilberg, G.,Parpounas, A.K.,Warren, A.L.,Yang, S.,Wacker, D. Molecular basis of human trace amine-associated receptor 1 activation. Nat Commun, 15:108-108, 2024 Cited by PubMed: 38168118 DOI: 10.1038/s41467-023-44601-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.35 Å)

Structure validation