8UH6

Degrader-induced complex between PTPN2 and CRBN-DDB1

Summary for 8UH6

• Entry DOI: 10.2210/pdb8uh6/pdb
• EMDB information: 42247
• Descriptor: DNA damage-binding protein 1, Protein cereblon, Tyrosine-protein phosphatase non-receptor type 2, ... (5 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 219118.76

Authors

Catalano, C.,Bratkowski, M.,Scapin, G.,Hao, Q. (deposition date: 2023-10-06, release date: 2024-09-11)

• Primary citation: Hao, Q.,Rathinaswamy, M.K.,Klinge, K.L.,Bratkowski, M.,Mafi, A.,Baumgartner, C.K.,Hamel, K.M.,Veits, G.K.,Jain, R.,Catalano, C.,Fitzgerald, M.,Hird, A.W.,Park, E.,Vora, H.U.,Henderson, J.A.,Longenecker, K.,Hutchins, C.W.,Qiu, W.,Scapin, G.,Sun, Q.,Stoll, V.S.,Sun, C.,Li, P.,Eaton, D.,Stokoe, D.,Fisher, S.L.,Nasveschuk, C.G.,Paddock, M.,Kort, M.E.; Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.; Commun Chem, 7:183-183, 2024; PubMed: 39152201; DOI: 10.1038/s42004-024-01263-7

Experimental method

ELECTRON MICROSCOPY (3.3 Å)