8UGS

Cryo-EM structure of bovine phosphodiesterase 6 bound to cGMP

Summary for 8UGS

Entry DOI	10.2210/pdb8ugs/pdb
Related	8UFI 8UGB
EMDB information	42234
Descriptor	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ... (6 entities in total)
Functional Keywords	phosphodiesterase, gpcr effector enzyme, signaling protein, inhibitor, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological source	Bos taurus (cattle) More
Total number of polymer chains	4
Total formula weight	218840.14
Authors	Aplin, C.,Cerione, R.A. (deposition date: 2023-10-06, release date: 2024-01-17, Last modification date: 2024-02-07)
Primary citation	Aplin, C.,Cerione, R.A. Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6. J.Biol.Chem., 300:105608-105608, 2023 Cited by PubMed: 38159849 DOI: 10.1016/j.jbc.2023.105608 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation