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8UGS

Cryo-EM structure of bovine phosphodiesterase 6 bound to cGMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0001750cellular_componentphotoreceptor outer segment
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007601biological_processvisual perception
A0008081molecular_functionphosphoric diester hydrolase activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0042622cellular_componentphotoreceptor outer segment membrane
A0042995cellular_componentcell projection
A0046872molecular_functionmetal ion binding
A0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
A0060041biological_processretina development in camera-type eye
A0097381cellular_componentphotoreceptor disc membrane
A0141162biological_processnegative regulation of cAMP/PKA signal transduction
B0001750cellular_componentphotoreceptor outer segment
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
B0007165biological_processsignal transduction
B0007601biological_processvisual perception
B0008081molecular_functionphosphoric diester hydrolase activity
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0042622cellular_componentphotoreceptor outer segment membrane
B0042995cellular_componentcell projection
B0043153biological_processentrainment of circadian clock by photoperiod
B0046872molecular_functionmetal ion binding
B0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
B0060041biological_processretina development in camera-type eye
B0097381cellular_componentphotoreceptor disc membrane
B0141162biological_processnegative regulation of cAMP/PKA signal transduction
C0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
C0007601biological_processvisual perception
C0008270molecular_functionzinc ion binding
C0016787molecular_functionhydrolase activity
C0030553molecular_functioncGMP binding
C0042622cellular_componentphotoreceptor outer segment membrane
C0043410biological_processpositive regulation of MAPK cascade
C0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
C0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
C0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
C0060090molecular_functionmolecular adaptor activity
C0097381cellular_componentphotoreceptor disc membrane
D0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
D0007601biological_processvisual perception
D0008270molecular_functionzinc ion binding
D0016787molecular_functionhydrolase activity
D0030553molecular_functioncGMP binding
D0042622cellular_componentphotoreceptor outer segment membrane
D0043410biological_processpositive regulation of MAPK cascade
D0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
D0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
D0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
D0060090molecular_functionmolecular adaptor activity
D0097381cellular_componentphotoreceptor disc membrane
Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDIdHrGtnNlY
ChainResidueDetails
AHIS599-TYR610
BHIS597-TYR608

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues298
DetailsDomain: {"description":"GAF 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues354
DetailsDomain: {"description":"GAF 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues666
DetailsDomain: {"description":"PDEase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01192","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues8
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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