8UFP

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-methyl-7-(4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)quinolin-2-amine dihydrochloride

Summary for 8UFP

Entry DOI	10.2210/pdb8ufp/pdb
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, (7M)-4-methyl-7-(4-methyl-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)quinolin-2-amine, ... (6 entities in total)
Functional Keywords	nitric oxide synthase inhibitor, heme enzyme, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	100845.83
Authors	Li, H.,Poulos, T.L. (deposition date: 2023-10-04, release date: 2024-03-13, Last modification date: 2024-04-03)
Primary citation	Li, H.,Hardy, C.D.,Reidl, C.T.,Jing, Q.,Xue, F.,Cinelli, M.,Silverman, R.B.,Poulos, T.L. Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry, 63:788-796, 2024 Cited by PubMed: 38417024 DOI: 10.1021/acs.biochem.3c00601 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation