8UD9

Structure of human constitutive 20S proteasome complexed with the inhibitor TDI-8304

Summary for 8UD9

• Entry DOI: 10.2210/pdb8ud9/pdb
• Related: 8G6E 8G6F
• EMDB information: 42148
• Descriptor: Proteasome subunit alpha type-6, Proteasome subunit beta type-3, Proteasome subunit beta type-2, ... (16 entities in total)
• Functional Keywords: 20s proteasome, inhibitor, human, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 28
• Total formula weight: 718946.82

Authors

Hsu, H.-C.,Li, H. (deposition date: 2023-09-28, release date: 2023-12-20, Last modification date: 2024-01-03)

• Primary citation: Hsu, H.C.,Li, D.,Zhan, W.,Ye, J.,Liu, Y.J.,Leung, A.,Qin, J.,Crespo, B.,Gamo, F.J.,Zhang, H.,Cui, L.,Roth, A.,Kirkman, L.A.,Li, H.,Lin, G.; Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors.; Nat Commun, 14:8302-8302, 2023; PubMed: 38097652; DOI: 10.1038/s41467-023-44077-2

Experimental method

ELECTRON MICROSCOPY (2.04 Å)