8UCD
Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab
Summary for 8UCD
Entry DOI | 10.2210/pdb8ucd/pdb |
EMDB information | 42124 |
Descriptor | Metalloreductase STEAP1, AMG 509 anti-STEAP1 Fab, heavy chain, AMG 509 anti-STEAP1 Fab, light chain, ... (7 entities in total) |
Functional Keywords | membrane protein, antibody, cancer, membrane protein-immune system complex, membrane protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 173750.62 |
Authors | Li, F.,Bailis, J.M.,Zhang, H. (deposition date: 2023-09-26, release date: 2023-11-22, Last modification date: 2024-01-24) |
Primary citation | Nolan-Stevaux, O.,Li, C.,Liang, L.,Zhan, J.,Estrada, J.,Osgood, T.,Li, F.,Zhang, H.,Case, R.,Murawsky, C.M.,Estes, B.,Moore, G.L.,Bernett, M.J.,Muchhal, U.,Desjarlais, J.R.,Staley, B.K.,Stevens, J.,Cooke, K.S.,Aeffner, F.,Thomas, O.,Stieglmaier, J.,Lee, J.L.,Coxon, A.,Bailis, J.M. AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer. Cancer Discov, 14:90-103, 2024 Cited by PubMed: 37861452DOI: 10.1158/2159-8290.CD-23-0984 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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