8UCB
IRAK4 in complex with compound 8
Summary for 8UCB
Entry DOI | 10.2210/pdb8ucb/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, 6-(difluoromethyl)-N-[(4R)-7-ethoxy-2-{[(3R)-oxolan-3-yl]methyl}imidazo[1,2-a]pyridin-6-yl]pyridine-2-carboxamide (3 entities in total) |
Functional Keywords | kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 140297.44 |
Authors | |
Primary citation | Evans, R.,Bolduc, P.N.,Pfaffenbach, M.,Gao, F.,May-Dracka, T.,Fang, T.,Hopkins, B.T.,Chodaparambil, J.V.,Henry, K.L.,Li, P.,Metrick, C.,Nelson, A.,Trapa, P.,Thomas, A.,Burkly, L.,Peterson, E.A. The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N -(6-methylpyrazolo[1,5- a ]pyrimidin-3-yl)imidazo[1,2- a ]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke. J.Med.Chem., 67:4676-4690, 2024 Cited by PubMed: 38467640DOI: 10.1021/acs.jmedchem.3c02226 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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