8UC9

SOS2 co-crystal structure with fragment bound (compound 9)

Summary for 8UC9

Entry DOI	10.2210/pdb8uc9/pdb
Descriptor	Son of sevenless homolog 2, 7-chloroquinolin-4-amine (3 entities in total)
Functional Keywords	sos2, nucleotide exchange factor, gef, kras, ras, signaling protein, fragment screening, fbld
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	57549.29
Authors	Gunn, R.J.,Lawson, J.D. (deposition date: 2023-09-26, release date: 2024-01-10, Last modification date: 2024-01-24)
Primary citation	Smith, C.R.,Chen, D.,Christensen, J.G.,Coulombe, R.,Fethiere, J.,Gunn, R.J.,Hollander, J.,Jones, B.,Ketcham, J.M.,Khare, S.,Kuehler, J.,Lawson, J.D.,Marx, M.A.,Olson, P.,Pearson, K.E.,Ren, C.,Tsagris, D.,Ulaganathan, T.,Van't Veer, I.,Wang, X.,Ivetac, A. Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. J.Med.Chem., 67:774-781, 2024 Cited by PubMed: 38156904 DOI: 10.1021/acs.jmedchem.3c02140 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.44 Å)

Structure validation