8U8A
Cryo-EM structure of LRRK2 bound to type II inhibitor ponatinib
Summary for 8U8A
Entry DOI | 10.2210/pdb8u8a/pdb |
EMDB information | 42019 |
Descriptor | Leucine-rich repeat serine/threonine-protein kinase 2, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, GUANOSINE-5'-DIPHOSPHATE (3 entities in total) |
Functional Keywords | cryo-em, parkinson's disease, kinase, lrrk2, type ii inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 574806.83 |
Authors | |
Primary citation | Zhu, H.,Hixson, P.,Ma, W.,Sun, J. Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Cell Discov, 10:10-10, 2024 Cited by PubMed: 38263358DOI: 10.1038/s41421-023-00639-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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