8U8A
Cryo-EM structure of LRRK2 bound to type II inhibitor ponatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, C | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 2527 | 286427.7 | 2 | UniProt (Q5S007) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF00069) In PDB | Homo sapiens (human) | Dardarin |
| 2 | B, C | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 2 | Chemie (0LI) | |||
| 3 | B, C | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) |
Sequence modifications
B, C: 1 - 2527 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| His 50 | Arg 50 | conflict |
| Thr 1647 | Ser 1647 | conflict |
| Thr 2397 | Met 2397 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 572855.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1951.5 | |
| All* | Total formula weight | 574806.8 |
