8U6S
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(3-morpholino-3-oxopropoxy)phenoxy)indolizine-2-carbonitrile (JLJ757), a non-nucleoside inhibitor
Summary for 8U6S
| Entry DOI | 10.2210/pdb8u6s/pdb |
| Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, (4S)-8-{2-[3-(morpholin-4-yl)-3-oxopropoxy]phenoxy}indolizine-2-carbonitrile, ... (6 entities in total) |
| Functional Keywords | reverse transcriptase, antiviral, drug design, hiv-1, viral protein |
| Biological source | Human immunodeficiency virus 1 More |
| Total number of polymer chains | 2 |
| Total formula weight | 114419.18 |
| Authors | Prucha, G.,Henry, S.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-09-13, release date: 2023-11-08) |
| Primary citation | Prucha, G.R.,Henry, S.,Hollander, K.,Carter, Z.J.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262:115894-115894, 2023 Cited by PubMed: 37883896DOI: 10.1016/j.ejmech.2023.115894 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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